Electrophoresis is the initial screening procedure to detect paraproteins

Educational material about protein electrophoresis

The Hellabio Agarose Gels for protein electrophoresis are intended to be used for in vitro diagnosis and enable the quantitative and qualitative estimation of proteins in serum and other biological fluids.

Serum Protein electrophoresis can be applied in a variety of clinical cases such as:

  • Suspicion of  multiple myeloma, macroglobulinemia, or amyloidosis.
  • Unexplained weakness or fatigue, anemia, elevation of the erythrocyte sedimentation’s rate, back pain, osteoporosis or osteolytic lesion, immunoglobulin deficiency, hypocalcaemia, Bence Jones proteinuria, renal insufficiency or recurrent infections.
  • Peripheral neuropathy, carpal tunnel syndrome, refractory congestive heart failure, nephrotic syndrome, orthostatic hypertension or malabsorption.

Schematic representation of the position of the proteins in electropherogram
Protein electrophoresis Poster
Serum Proteins increase - decrease
Electrophoresis on Agarose gel is the most common method currently in use in clinical diagnostic for the detection of paraproteins in serum and urine.
Electrophoresis is the only reliable technique to detect paraproteins in biological fluids
Where a BJP is present in significant concentrations (>100mg/l) with no accompanying glomerular or tubular proteinuria, detection is straightforward by Immunofixation.

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