Normal reference values can vary by laboratory, but are generally within the following ranges.
- Hgb A: 95-98%
- Hgb A2: 1.5-3.5%
- Hgb F: 0.8-2.0%
- Hgb S: 0%
- Hgb C: 0%.
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- greater than 6 months: 1-2%
- 6 months: 8%
- newborn (Hgb F): 50-80
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What abnormal results mean:
- The presence of significant levels of abnormal hemoglobins may indicate:
- Hemoglobin C disease
- Rare hemoglobinopathy
- Sickle cell anemia
- Thalassemia is an additional condition under which the test may be performed.
Special considerations:
A blood transfusion within the previous 12 weeks can produce falsely normal or abnormal results.
Abnormal results:
Abnormal reference values can vary by laboratory, but when they appear within these ranges, results are usually associated with the conditions that follow in parentheses.
Hgb A2:
- 4-5.8% (thalassemia minor)
- under 2% (Hb H disease)
Hgb F:
- 10-90% (thalassemia major)
- 5-35% (Heterozygous hereditary persistence of fetal hemoglobin, or HPFH)
- 100% (Homozygous HPFH)
- 15% (Homozygous Hgb S)
Homozygous Hgb S:
- 70-98% (Sickle cell disease).
Homozygous Hgb C: